Intracranial abscess include cerebral abscess, subdural empyema and epidural empyema. It is defined as a focal, encapsulated infection of cerebral parenchyma and is caused by a wide array of microorganisms such as bacteria, mycobacteria, protozoa, fungi or helminths. Treatment for this indication is challenging as it’s difficult to penetrate the blood brain barrier.
HBOT as an adjunctive therapy directly address the physiologic challenges in treating intracranial abscesses. Increased partial pressures of oxygen correct the tissue hypoxia and exert bacteriostatic and bactericidal effects, particularly with anerobic organisms.
- Enhances effect of antibiotic agent and neutrophil-mediated phagocytosis of infecting organisms
- Reduced brain swelling, resulting in decreased intracranial pressure
- Bacteriostatic and bactericidal
- Decreased morbidity and mortality rate