Problem wounds represent a significant and growing challenge to healthcare. Venous leg ulcers represent the most common lower extremity wound seen in wound care centers followed closely by diabetic foot ulcers. Foot ulcers in patients with diabetes contribute to over half of lower extremity amputations in the United States.
Factors negatively affecting wound healing include persistent infection, poor perfusion and hypoxia, cellular failure, and unrelieved pressure or recurrent trauma.Hypoxia can be directly correlated to impaired wound healing and an increase in wound infection.Tissue oxygen tensions surrounding the wound are about half of the normal values found in normal, non-wounded tissue.The rate at which normal wounds heal is proven to be oxygen dependent.
- Fibroblast replication
- Collagen deposition
- resistance to infection
- intracellular leukocyte bacterial killing